HMGBiotech产品代理
HMGBiotech产品代理
HMGB1 是细胞核的一个组成部分，在基因组的组织和表达中具有多种功能。当细胞因损伤（病毒、机械或化学创伤、中毒）而死亡时，HMGB1 会被释放并被附近细胞中的受体接收。此外，处于严重压力下的细胞甚至在死亡前也会分泌 HMGB1。存活的细胞产生一线反应——炎症——并尝试替换死细胞并重建受损组织。 HMGB1 促进恢复和再生，例如梗塞后心脏的恢复和再生。然而，过多的 HMGB1 与败血症（过度炎症导致急性痛苦并最终死亡）、关节炎、动脉粥样硬化和癌症转移有关。
HMGBiotech srl 为活跃在这个有前途领域的其他研究人员和公司提供试剂、服务和想法。它还帮助 Bianchi 实验室开发检测方法和试剂。
HMGBiotech 在意大利米兰 via Olgettina 58, 20133 的 OSR 内设有研发和生产部门
HMGBiotech is a biotech company founded by Marco E. Bianchi, a leading scientist in the HMGB field.
HMGB1 is a component of the cell nucleus, with multiple functions in the organization and expression of the genome. When a cell dies because of an insult (a virus, a mechanical or chemical trauma, poisoning) HMGB1 is released and is picked up by receptors in nearby cells. In addition, cells under severe stress secrete HMGB1 even before dying. Surviving cells mount a firstline response -inflammation- and try to replace the dead cells and reconstruct the damaged tissue. HMGB1 promotes recovery and regeneration, for example of the heart after infarction. However, too much HMGB1 is associated to sepsis (excessive inflammation leading to acute distress and eventually death), arthritis, atherosclerosis, and cancer metastasis.
HMGBiotech srl provides reagents, services and ideas to other researchers and companies active in this promising field. It also helps the Bianchi lab in developing assays and reagents.
HMGBiotech has R&D and production unit within OSR in via Olgettina 58, 20133 Milano, Italy
