cellscript产品代理
cellscript产品代理
目前的产品包括体外转录试剂盒、使用帽类似物或加帽酶的 5' RNA 加帽和 3' RNA 多聚腺苷酸化，以及用于制备加帽、poly(A) 尾 mRNA 以进行翻译的多合一试剂盒 在细胞中。
CELLSCRIPT™ 最近推出了 INCOGNITO™ RNA 转录试剂盒，用于体外合成含有修饰核苷的 RNA，例如假尿苷 (Ψ) 和/或 5-甲基胞苷 (m5C) 代替相应的 U 或 C 经典核苷（图 1）。 这些试剂盒之所以如此命名是因为加帽、多腺苷酸化和核苷修饰的 RNA 产物（称为“INCOGNITO mRNA”）是伪装的，因此当它们转染到表达 各种RNA传感器。
The mission of CELLSCRIPT™ is to provide the best products and technologies for making and using RNA for translation in cells for clinical research and therapeutics.
Current products include kits for in vitro transcription, 5' RNA capping using either a cap analog or capping enzymes, and 3' RNA polyadenylation, as well as all-in-one kits for making capped, poly(A)-tailed mRNA for translation in cells.
CELLSCRIPT™ recently introduced INCOGNITO™ RNA Transcription Kits for in vitro synthesis of RNA that contains modified nucleosides, such as pseudouridine (Ψ) and/or 5-methylcytidine (m5C) in place of the corresponding U or C canonical nucleosides (Figure 1). These kits are so-named because the capped, polyadenylated and nucleoside-modified RNA products (called "INCOGNITO mRNAs") are disguised so they do not induce innate immune responses to the same extent as the corresponding unmodified mRNAs when transfected into mammalian cells that express a variety of RNA sensors.
