chimerigen产品代理
chimerigen产品代理
Chimerigen 使用先进的细胞和分子生物学技术制造独特的基于免疫球蛋白的嵌合融合蛋白及其相关研究产品。这些试剂已成功用于基础和应用研究。
此外，Chimerigen 还提供高质量的服务来生产和纯化定制的蛋白质。 Chimerigen 保证客户的满意。此外，Chimerigen 保护客户对其蛋白质的权利。
有两种类型的 IL2-Fc。两种形式都是可溶性 97kDa 二聚体融合蛋白，由与天然或突变小鼠 IgG2a Fc 融合的小鼠 IL-2 组成。非溶解性 IL-2/Fc 充当长效 IL-2。溶解性 IL-2/Fc 不仅与 IL-2R 结合，还能够介导 ADCC 和 CDC 免疫效应机制以靶向 IL-2R 阳性细胞。
细胞因子调节免疫反应的潜在临床应用非常高。不幸的是，大多数细胞因子的循环半衰期都很短。随着一组新的基于免疫球蛋白的细胞因子融合蛋白的产生，其中细胞因子序列已经遗传融合到免疫球蛋白的铰链、CH2 和 CH3 区，这些细胞因子融合蛋白同时具有细胞因子部分的生物学功能和由 Fc 结构域决定的延长的循环半衰期。
Chimerigen is a biotechnology company which develops, manufactures, and markets high quality, leading edge products for biomedical research. The company leverages its
technological strengths to develop innovative reagents for biomedical research.
Chimerigen manufactures unique immunoglobulin based chimeric fusion proteins and their related research products using advanced cellular and molecular biological techniques. These reagents are used successfully in basic and applied research.
In addition, Chimerigen provides high quality service to produce and purify customized proteins. Chimerigen guarantees customer's satisfactions. Moreover, Chimerigen protects customer's right on their proteins.
There are two types of IL2-Fc. Both forms are a soluable 97kDa dimeric fusion protein consisting of mouse IL-2 fused to natic or mutant mouse IgG2a Fc. Nonlytic IL-2/Fc acts as long-lasting IL-2. Lytic IL-2/Fc not only binds to IL-2R, it is capable to mediate ADCC and CDC immune effector mechanism to target IL-2R positive cells.
The potential clinical application of cytokines to modulate immune response is very high. Unfortunately, most cytokines have short circulating half-lives. With the creation of a group of new immunoglobulin- based cytokine fusion proteins, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin, these cytokine fusion proteins possess both the biological functions of the cytokine moiety and the prolonged circulating half-life
determined by the Fc domain.
