contrafect产品代理

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contrafect产品代理

ContraFect 是一家临床阶段的生物技术公司,专注于发现和开发针对危及生命的耐药传染病的生物疗法,特别是那些在医院环境中治疗的传染病。据估计,全世界每年有 700,000 人死于抗微生物药物耐药性感染。我们打算使用来自我们的直接裂解剂 (DLA) 平台的治疗产品候选者来解决威胁生命的感染,其中包括溶素和 amurin 肽。我们相信 DLA 提供了机会,可以对临床结果进行有意义的改善,并改变感染抗生素耐药性细菌的患者的治疗模式。我们最初的候选产品是治疗致命的耐药感染的新药物,例如耐甲氧西林金黄色葡萄球菌 (MRSA) 和革兰氏阴性病原体,如多重耐药 (MDR) 铜绿假单胞菌。
我们的治疗产品候选者是直接溶解剂 (DLA),它代表了治疗细菌感染方法的一种新的、潜在的范式转变,包括由耐药病原体引起的感染。我们的重点是为患者实现优于当前护理标准的临床结果。
当细菌和病毒等微生物以允许它们在抗生素和抗病毒治疗的情况下生长的方式发生变化时,就会出现耐药性。抗生素的过度使用导致耐药细菌(如 MRSA)的流行率急剧增加,这些细菌需要更长和更昂贵的治疗过程,并且与大量的发病率和死亡率有关。
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ContraFect   is a clinical-stage biotechnology company focused on discovering and   developing biologic therapies for life-threatening, drug-resistant infectious   diseases, particularly those treated in hospital settings. An estimated   700,000 deaths worldwide each year are attributed to antimicrobial-resistant   infections. We intend to address life threatening infections using our   therapeutic product candidates from our platform of direct lytic agents   (DLAs), which include lysins and amurin peptides. We believe DLAs provide the   opportunity to make meaningful improvements to clinical outcomes and to   change the treatment paradigm for patients infected with antibiotic-resistant   bacteria. Our initial product candidates are new agents to treat lethal,   resistant infections such as methicillin-resistant Staph aureus (MRSA) and   Gram-negative pathogens like multi-drug resistant (MDR) Pseudomonas   aeruginosa.

Our   therapeutic product candidates are direct lytic agents (DLAs) that represent   a new, potential paradigm shift in the approach to treating bacterial   infections, including those caused by drug-resistant pathogens.  Our focus is on achieving superior clinical   outcomes for patients over current standard of care.

   

Drug resistance occurs when microbes such as bacteria and viruses change in ways that allow them to grow despite antibiotic and antiviral treatment. Overuse of antibiotics has contributed to dramatic increases in the prevalence of drug resistant bacteria, such as MRSA, which require longer and more expensive courses of treatment and are associated with substantial morbidity and mortality.