On-chip 产品代理

CELL SORTER: ON-CHIP SORT

CONSUMABLES: MICROFLUIDIC CHIP

CONSUMABLES: REAGENTS

CELL DISPENSER: ON-CHIP SPiS

On-chip Biotechnologies, incorporated in 2005, is the first company in the world to launch a microfluidic chip-based cell sorter on the market. Our microfluidic chip-based cell sorter, On-chip Sort, designed and manufactured in Japan, uses a disposable microfluidic chip as the core of its technology. Our microfluidic chips are manufactured with Japan’s outstanding high-precision plastic injection molding technology.

Flow cytometer is commonly used in the biomedical field for cell sorting. This allows cells of interest to be isolated from a heterogenous sample. Cells can be easily stained and passed through a cell sorter to be analysed or sorted, which is useful if the necessity is only sorting. In many cases where cells are used for further downstream analyses, researchers have noticed changes in their cells post-sorting (i.e., morphological changes, delayed cell growth, decrease in cell viability and alterations in gene expression). The post-sorting cell changes are a result of “sorter-induced cellular stress” (SICS).

SICS arose from the cell sorting technique used in most cell sorting systems known as Jet-in-air method. With this method, the use of high pressure for manipulation of sample, the large pressure differentials inside and outside the nozzle, the use of electric charges to deflect droplets into collection chamber, and high-speed collisions during collection, can all lead to SICS. Therefore, as a prevention for post-sorting cell changes with conventional cell sorter, we developed On-chip Sort. On-chip Sort employs a unique cell sorting mechanism to eliminate all the damaging steps involved in cell sorting on conventional sorters to significantly reduce SICS.

On-chip’s vision: To assist researchers in accelerating the world’s new discoveries in life science, drug development and diagnostics with On-chip Sort.