qvquality 产品代理

domain antibodies

QVQ offers tailor-made VHH-development on inquiry. This includes:

– Design and implementation of an immunization protocols in llama

– Determination of immune responses in the sera

– Cloning of VHH-repertoires in phage-display libraries

– Delivery of different VHHs (sequence and >0.5 mg protein)

QVQ can also deliver larger quantities of VHH for their prospective use in for example (co-)crystallization or in vivo experiments. In addition, QVQ offers directional labeling of VHHs and the oppertunity to produce VHHs in yeast according to GMP conditions, which allows for clinical application.

QVQ Mission

QVQ aims for an accurate and sensitive detection of diseases in an early stage. In order to achieve this, QVQ collaborates closely with top academic groups and industrial partners to deliver top quality and validated imaging and research agents that are based on directionally conjugated single domain antibodies (functionalized VHH).

Main Services and Products

QVQ’s main product is based on a small, high affinity single domain antibody fragment from camelids (VHH). Upon request, these VHHs can be tailor-made into mono-, bi- and even multispecific formats. To facilitate excellent detection (imaging) and for example affinity purification, QVQ offers directional conjugation of VHHs to a variety of tracers using its proprietary C-direct tag and sufhydryl-maleimide coupling. Because the free thiol in the C-direct tag is positioned distal of the antigen-binding loops of the VHH, QVQs conjugates maintain the original binding integrity of the VHHs. QVQ strives to provide the same VHH with different modalities and probes to enable all imaging applications in a correlative way, ranging from ELISA, IHC, to optical and electron microscopy.